up-to-date information on the largest online casino as the online gambling industry is constantly evolving. The rankings and sizes of online casinos can change over time due to various factors such as mergers, acquisitions, and market fluctuations.some of the well-known and reputable online casinos that were prominent as of September 2021 include: 1.Bet365 Casino,888 Casino,LeoVegas Casino,William Hill ,Casino,Casumo Casino,Royal Panda Casino ,PlayOJO Casino,Mr Green Casino,Bitstarz CasinoSpin Casino,It's important to note that the size and reputation of online casinos can vary depending on different factors, such as the regions they operate in, the range of games they offer, customer support, payment methods, and overall user experience. If you're looking for the largest online casino at the current time, I recommend doing some research or referring to reputable online gambling resources for the most up-to-date information.